Inverse Agonist and Pharmacochaperone Properties of MK-0524 on the Prostanoid DP1 Receptor

Prostaglandin D(2) (PGD(2)) acts through two G protein-coupled receptors (GPCRs), the prostanoid DP receptor and CRTH2 also known as DP1 and DP2, respectively. Several previously characterized GPCR antagonists are now classified as inverse agonists and a number of GPCR ligands are known to display p...

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Detalles Bibliográficos
Autores principales: Labrecque, Pascale, Roy, Sébastien J., Fréchette, Louis, Iorio-Morin, Christian, Gallant, Maxime A., Parent, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677937/
https://www.ncbi.nlm.nih.gov/pubmed/23762421
http://dx.doi.org/10.1371/journal.pone.0065767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677937/
https://www.ncbi.nlm.nih.gov/pubmed/23762421
http://dx.doi.org/10.1371/journal.pone.0065767

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