The role of endoplasmic reticulum stress in maintaining and targeting multiple myeloma: a double-edged sword of adaptation and apoptosis

Increased cellular protein production places stress on the endoplasmic reticulum (ER), because many of the nascent proteins pass through the ER for folding and trafficking. Accumulation of misfolded proteins in the ER triggers the activation of three well-known pathways including IRE1 (inositol requ...

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Detalles Bibliográficos
Autores principales: White-Gilbertson, Shai, Hua, Yunpeng, Liu, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678081/
https://www.ncbi.nlm.nih.gov/pubmed/23781234
http://dx.doi.org/10.3389/fgene.2013.00109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678081/
https://www.ncbi.nlm.nih.gov/pubmed/23781234
http://dx.doi.org/10.3389/fgene.2013.00109

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