Exome and whole genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

The incidence of esophageal adenocarcinoma (EAC) has risen 600% over the last 30 years. With a five-year survival rate of 15%, identification of new therapeutic targets for EAC is greatly important. We analyze the mutation spectra from whole exome sequencing of 149 EAC tumors/normal pairs, 15 of whi...

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Detalles Bibliográficos
Autores principales: Dulak, Austin M., Stojanov, Petar, Peng, Shouyong, Lawrence, Michael S., Fox, Cameron, Stewart, Chip, Bandla, Santhoshi, Imamura, Yu, Schumacher, Steven E., Shefler, Erica, McKenna, Aaron, Cibulskis, Kristian, Sivachenko, Andrey, Carter, Scott L., Saksena, Gordon, Voet, Douglas, Ramos, Alex H., Auclair, Daniel, Thompson, Kristin, Sougnez, Carrie, Onofrio, Robert C., Guiducci, Candace, Beroukhim, Rameen, Zhou, David, Lin, Lin, Lin, Jules, Reddy, Rishindra, Chang, Andrew, Luketich, James D., Pennathur, Arjun, Ogino, Shuji, Golub, Todd R., Gabriel, Stacey B., Lander, Eric S., Beer, David G., Godfrey, Tony E., Getz, Gad, Bass, Adam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678719/
https://www.ncbi.nlm.nih.gov/pubmed/23525077
http://dx.doi.org/10.1038/ng.2591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678719/
https://www.ncbi.nlm.nih.gov/pubmed/23525077
http://dx.doi.org/10.1038/ng.2591

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