Integrated genomic analyses identify WEE1 as a critical mediator of cell fate and novel therapeutic target in acute myeloid leukemia

Acute myeloid leukemia (AML) remains a therapeutic challenge despite increasing knowledge about the molecular origins of the disease, as the mechanisms of AML cell escape from chemotherapy remain poorly defined. We hypothesized that AML cells are addicted to molecular pathways in the context of chem...

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Detalles Bibliográficos
Autores principales: Porter, Christopher C., Kim, Jihye, Fosmire, Susan, Gearheart, Christy M., van Linden, Annemie, Baturin, Dmitry, Zaberezhnyy, Vadym, Patel, Purvi R., Gao, Dexiang, Tan, Aik Choon, DeGregori, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678731/
https://www.ncbi.nlm.nih.gov/pubmed/22289989
http://dx.doi.org/10.1038/leu.2011.392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678731/
https://www.ncbi.nlm.nih.gov/pubmed/22289989
http://dx.doi.org/10.1038/leu.2011.392

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