Fbw7 Repression by Hes5 Creates a Feedback Loop That Modulates Notch-Mediated Intestinal and Neural Stem Cell Fate Decisions

FBW7 is a crucial component of an SCF-type E3 ubiquitin ligase, which mediates degradation of an array of different target proteins. The Fbw7 locus comprises three different isoforms, each with its own promoter and each suspected to have a distinct set of substrates. Most FBW7 targets have important...

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Detalles Bibliográficos
Autores principales: Sancho, Rocio, Blake, Sophia M., Tendeng, Christian, Clurman, Bruce E., Lewis, Julian, Behrens, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679002/
https://www.ncbi.nlm.nih.gov/pubmed/23776410
http://dx.doi.org/10.1371/journal.pbio.1001586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679002/
https://www.ncbi.nlm.nih.gov/pubmed/23776410
http://dx.doi.org/10.1371/journal.pbio.1001586

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