Cdk4 and Nek2 Signal Binucleation and Centrosome Amplification in a Her2+ Breast Cancer Model

Centrosome amplification (CA) is a contributor to carcinogenesis, generating aneuploidy, and chromosome instability. Previous work shows that breast adenocarcinomas have a higher frequency of centrosome defects compared to normal breast tissues. Abnormal centrosome phenotypes are found in pre-malign...

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Detalles Bibliográficos
Autores principales: Harrison Pitner, Mary Kathryn, Saavedra, Harold I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679029/
https://www.ncbi.nlm.nih.gov/pubmed/23776583
http://dx.doi.org/10.1371/journal.pone.0065971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679029/
https://www.ncbi.nlm.nih.gov/pubmed/23776583
http://dx.doi.org/10.1371/journal.pone.0065971

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