Cargando…

HIF-1α Inhibits Wnt Signaling Pathway by Activating Sost Expression in Osteoblasts

The nature of the cellular and molecular mechanisms for the transition of avascular cartilage replacement with bone during endochondral ossification remains poorly understood. One of the driving forces is hypoxia. As a master regulator of hypoxia, hypoxia-inducible factor-1α (HIF-1α) has been report...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Dafu, Li, Yang, Zhou, Zhiyu, Wu, Chengai, Xing, Yonggang, Zou, Xuenong, Tian, Wei, Zhang, Chi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679053/ https://www.ncbi.nlm.nih.gov/pubmed/23776575 http://dx.doi.org/10.1371/journal.pone.0065940

Ejemplares similares

Synergistic Inhibition of Wnt Pathway by HIF-1α and Osteoblast-Specific Transcription Factor Osterix (Osx) in Osteoblasts
por: Chen, Dafu, et al.
Publicado: (2012)

ERβ compensates for the absence of ERα function to promote osteoblast viability by inhibition of SOST signaling
por: Lu, Shijin, et al.
Publicado: (2017)

Wnt Inhibitors Dkk1 and Sost Are Downstream Targets of BMP Signaling Through the Type IA Receptor (BMPRIA) in Osteoblasts
por: Kamiya, Nobuhiro, et al.
Publicado: (2010)

Genetics and Genomics of SOST: Functional Analysis of Variants and Genomic Regulation in Osteoblasts
por: Martínez-Gil, Núria, et al.
Publicado: (2021)

COX2 is involved in hypoxia-induced TNF-α expression in osteoblast
por: Xing, Yonggang, et al.
Publicado: (2015)

SOST Inhibits Prostate Cancer Invasion
por: Hudson, Bryan D., et al.
Publicado: (2015)

Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt Antagonist Sost Is Mediated by Estrogen Receptor β
por: Galea, Gabriel L., et al.
Publicado: (2013)

Cancer–Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer
por: Sebastian, Aimy, et al.
Publicado: (2015)

Reduction of SOST gene promotes bone formation through the Wnt/β‐catenin signalling pathway and compensates particle‐induced osteolysis
por: Zhang, Zai Hang, et al.
Publicado: (2020)

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4
por: Galea, Gabriel L., et al.
Publicado: (2011)

Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway
por: Li, Luyao, et al.
Publicado: (2022)

Common and rare variants of WNT16, DKK1 and SOST and their relationship with bone mineral density
por: Martínez-Gil, Núria, et al.
Publicado: (2018)

Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5
por: Diegel, Cassandra R., et al.
Publicado: (2023)

SOST gene suppression stimulates osteocyte Wnt/β-catenin signaling to prevent bone resorption and attenuates particle-induced osteolysis
por: Jiao, Zixue, et al.
Publicado: (2023)

Osteocyte Network; a Negative Regulatory System for Bone Mass Augmented by the Induction of Rankl in Osteoblasts and Sost in Osteocytes at Unloading
por: Moriishi, Takeshi, et al.
Publicado: (2012)

Regulation of Osteoblast Metabolism by Wnt Signaling
por: Moorer, Megan C., et al.
Publicado: (2018)

WNT-5a and SOST Levels in Gingival Crevicular Fluid Depend on the Inflammatory and Osteoclastogenic Activities of Periodontal Tissues
por: Chatzopoulos, Georgios S., et al.
Publicado: (2021)

Blood and bones: Osteoblastic HIF signaling regulates erythropoiesis
por: Wu, Colleen, et al.
Publicado: (2012)

SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease
por: Mason, James J., et al.
Publicado: (2010)

An oxygen-insensitive Hif-3α isoform inhibits Wnt signaling by destabilizing the nuclear β-catenin complex
por: Zhang, Peng, et al.
Publicado: (2016)

Expression of SOST/sclerostin in compressed periodontal ligament cells
por: Ueda, Masae, et al.
Publicado: (2016)

A Novel Mutation in SOST Gene Causes Sclerosteosis
por: Alyusuf, Ebtihal Y, et al.
Publicado: (2021)

Erythropoietin inhibits osteoblast function in myelodysplastic syndromes via the canonical Wnt pathway
por: Balaian, Ekaterina, et al.
Publicado: (2018)

1,25-dihydroxyvitamin D(3) Activates MMP13 Gene Expression in Chondrocytes through p38 MARK Pathway
por: Chen, Dafu, et al.
Publicado: (2013)

Interleukin 6/Wnt interactions in rheumatoid arthritis: interleukin 6 inhibits Wnt signaling in synovial fibroblasts and osteoblasts
por: Malysheva, Khrystyna, et al.
Publicado: (2016)

Anatomical similarity between the Sost‐knockout mouse and sclerosteosis in humans
por: Schwarze, Uwe Y., et al.
Publicado: (2019)

SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury
por: Chang, Jiun C, et al.
Publicado: (2018)

Sodium Selenite Promotes Osteoblast Differentiation via The WNT/ß-Catenin Signaling Pathway
por: Sharma, Ashish Ranjan, et al.
Publicado: (2022)

β-elemene inhibits radiation and hypoxia-induced macrophages infiltration via Prx-1/NF-κB/HIF-1α signaling pathway
por: Yu, Xiaomu, et al.
Publicado: (2019)

RASA4 inhibits the HIFα signaling pathway to suppress proliferation of cervical cancer cells
por: Chen, Junying, et al.
Publicado: (2021)

MiR-17 Partly Promotes Hematopoietic Cell Expansion through Augmenting HIF-1α in Osteoblasts
por: Yang, Yuxia, et al.
Publicado: (2013)

HIF-1α is Overexpressed in Odontogenic Keratocyst Suggesting Activation of HIF-1α and NOTCH1 Signaling Pathways
por: Miranda da Costa, Natacha Malu, et al.
Publicado: (2019)

Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo
por: Basha, Genc, et al.
Publicado: (2016)

Polygonatum sibiricum polysaccharide inhibits osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through Wnt/β-catenin signalling pathway
por: Du, Li, et al.
Publicado: (2016)

Sost Deficiency does not Alter Bone’s Lacunar or Vascular Porosity in Mice
por: Mosey, Henry, et al.
Publicado: (2017)

SOST Deficiency Aggravates Osteoarthritis in Mice by Promoting Sclerosis of Subchondral Bone
por: Li, Jingyu, et al.
Publicado: (2019)

EFFECT OF PKP ON SERUM SOST IN PATIENTS WITH VERTEaBRAL COMPRESSION FRACTURES
por: WANG, ENZHI, et al.
Publicado: (2020)

ATF5 and HIF1α cooperatively activate HIF1 signaling pathway in esophageal cancer
por: He, Feng, et al.
Publicado: (2021)

The metabolic bone disease associated with the Hyp mutation is independent of osteoblastic HIF1α expression
por: Hum, Julia M., et al.
Publicado: (2017)

p38/TF/HIF-α Signaling Pathway Participates in the Progression of CIPN in Mice
por: Yang, Yang, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_t44tus9uh6gi4b8750s8t398ke