Epitope Mapping of M36, a Human Antibody Domain with Potent and Broad HIV-1 Inhibitory Activity

M36 is the first member of a novel class of potent HIV-1 entry inhibitors based on human engineered antibody domains (eAds). It exhibits broad inhibitory activity suggesting that its CD4-induced epitope is highly conserved. Here, we describe fine mapping of its epitope by using several approaches. F...

Descripción completa

Detalles Bibliográficos
Autores principales: Wan, Chao, Sun, Jianping, Chen, Weizao, Yuan, Xiaohui, Chong, Huihui, Prabakaran, Ponraj, Dimitrov, Dimiter S., He, Yuxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679054/
https://www.ncbi.nlm.nih.gov/pubmed/23776690
http://dx.doi.org/10.1371/journal.pone.0066638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679054/
https://www.ncbi.nlm.nih.gov/pubmed/23776690
http://dx.doi.org/10.1371/journal.pone.0066638

Ejemplares similares