Functional Assessment of Population and Tumor-Associated APE1 Protein Variants

Apurinic/apyrimidinic endonuclease 1 (APE1) is the predominant AP site repair enzyme in mammals. APE1 also maintains 3′–5′ exonuclease and 3′-repair activities, and regulates transcription factor DNA binding through its REF-1 function. Since complete or severe APE1 deficiency leads to embryonic leth...

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Detalles Bibliográficos
Autores principales: Illuzzi, Jennifer L., Harris, Nicole A., Manvilla, Brittney A., Kim, Daemyung, Li, Mengxia, Drohat, Alexander C., Wilson, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679070/
https://www.ncbi.nlm.nih.gov/pubmed/23776569
http://dx.doi.org/10.1371/journal.pone.0065922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679070/
https://www.ncbi.nlm.nih.gov/pubmed/23776569
http://dx.doi.org/10.1371/journal.pone.0065922

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