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Elevated Levels of CD4(+)CD25(+)FoxP3(+) T Cells in Systemic Sclerosis Patients Contribute to the Secretion of IL-17 and Immunosuppression Dysfunction

OBJECTIVE: Immune imbalance between regulatory T (Treg) and Th17 cells is a characteristic of systemic sclerosis (SSc). The functional heterogeneity among Treg can be elucidated by separating Treg into different subsets based on the expression of FoxP3 and CD45RA. The aim of this study was to invest...

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Detalles Bibliográficos
Autores principales: Liu, Xinjuan, Gao, Na, Li, Mengtao, Xu, Dong, Hou, Yong, Wang, Qian, Zhang, Guohua, Sun, Qiuning, Zhang, Henghui, Zeng, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679128/
https://www.ncbi.nlm.nih.gov/pubmed/23776439
http://dx.doi.org/10.1371/journal.pone.0064531