The homologous recombination machinery modulates the formation of RNA–DNA hybrids and associated chromosome instability

Genome instability in yeast and mammals is caused by RNA–DNA hybrids that form as a result of defects in different aspects of RNA biogenesis. We report that in yeast mutants defective for transcription repression and RNA degradation, hybrid formation requires Rad51p and Rad52p. These proteins normal...

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Detalles Bibliográficos
Autores principales: Wahba, Lamia, Gore, Steven K, Koshland, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679537/
https://www.ncbi.nlm.nih.gov/pubmed/23795288
http://dx.doi.org/10.7554/eLife.00505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679537/
https://www.ncbi.nlm.nih.gov/pubmed/23795288
http://dx.doi.org/10.7554/eLife.00505

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