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Genetic dissection of growth traits in a Chinese indigenous × commercial broiler chicken cross

BACKGROUND: In China, consumers often prefer indigenous broiler chickens over commercial breeds, as they have characteristic meat qualities requested within traditional culinary customs. However, the growth-rate of these indigenous breeds is slower than that of the commercial broilers, which means t...

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Autores principales: Sheng, Zheya, Pettersson, Mats E, Hu, Xiaoxiang, Luo, Chenglong, Qu, Hao, Shu, Dingming, Shen, Xia, Carlborg, Örjan, Li, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679733/
https://www.ncbi.nlm.nih.gov/pubmed/23497136
http://dx.doi.org/10.1186/1471-2164-14-151
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author Sheng, Zheya
Pettersson, Mats E
Hu, Xiaoxiang
Luo, Chenglong
Qu, Hao
Shu, Dingming
Shen, Xia
Carlborg, Örjan
Li, Ning
author_facet Sheng, Zheya
Pettersson, Mats E
Hu, Xiaoxiang
Luo, Chenglong
Qu, Hao
Shu, Dingming
Shen, Xia
Carlborg, Örjan
Li, Ning
author_sort Sheng, Zheya
collection PubMed
description BACKGROUND: In China, consumers often prefer indigenous broiler chickens over commercial breeds, as they have characteristic meat qualities requested within traditional culinary customs. However, the growth-rate of these indigenous breeds is slower than that of the commercial broilers, which means they have not yet reached their full economic value. Therefore, combining the valuable meat quality of the native chickens with the efficiency of the commercial broilers is of interest. In this study, we generated an F(2) intercross between the slow growing native broiler breed, Huiyang Beard chicken, and the fast growing commercial broiler breed, High Quality chicken Line A, and used it to map loci explaining the difference in growth rate between these breeds. RESULTS: A genome scan to identify main-effect loci affecting 24 growth-related traits revealed nine distinct QTL on six chromosomes. Many QTL were pleiotropic and conformed to the correlation patterns observed between phenotypes. Most of the mapped QTL were found in locations where growth QTL have been reported in other populations, although the effects were greater in this population. A genome scan for pairs of interacting loci identified a number of additional QTL in 10 other genomic regions. The epistatic pairs explained 6–8% of the residual phenotypic variance. Seven of the 10 epistatic QTL mapped in regions containing candidate genes in the ubiquitin mediated proteolysis pathway, suggesting the importance of this pathway in the regulation of growth in this chicken population. CONCLUSIONS: The main-effect QTL detected using a standard one-dimensional genome scan accounted for a significant fraction of the observed phenotypic variance in this population. Furthermore, genes in known pathways present interesting candidates for further exploration. This study has thus located several QTL regions as promising candidates for further study, which will increase our understanding of the genetic mechanisms underlying growth-related traits in chickens.
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spelling pubmed-36797332013-06-25 Genetic dissection of growth traits in a Chinese indigenous × commercial broiler chicken cross Sheng, Zheya Pettersson, Mats E Hu, Xiaoxiang Luo, Chenglong Qu, Hao Shu, Dingming Shen, Xia Carlborg, Örjan Li, Ning BMC Genomics Research Article BACKGROUND: In China, consumers often prefer indigenous broiler chickens over commercial breeds, as they have characteristic meat qualities requested within traditional culinary customs. However, the growth-rate of these indigenous breeds is slower than that of the commercial broilers, which means they have not yet reached their full economic value. Therefore, combining the valuable meat quality of the native chickens with the efficiency of the commercial broilers is of interest. In this study, we generated an F(2) intercross between the slow growing native broiler breed, Huiyang Beard chicken, and the fast growing commercial broiler breed, High Quality chicken Line A, and used it to map loci explaining the difference in growth rate between these breeds. RESULTS: A genome scan to identify main-effect loci affecting 24 growth-related traits revealed nine distinct QTL on six chromosomes. Many QTL were pleiotropic and conformed to the correlation patterns observed between phenotypes. Most of the mapped QTL were found in locations where growth QTL have been reported in other populations, although the effects were greater in this population. A genome scan for pairs of interacting loci identified a number of additional QTL in 10 other genomic regions. The epistatic pairs explained 6–8% of the residual phenotypic variance. Seven of the 10 epistatic QTL mapped in regions containing candidate genes in the ubiquitin mediated proteolysis pathway, suggesting the importance of this pathway in the regulation of growth in this chicken population. CONCLUSIONS: The main-effect QTL detected using a standard one-dimensional genome scan accounted for a significant fraction of the observed phenotypic variance in this population. Furthermore, genes in known pathways present interesting candidates for further exploration. This study has thus located several QTL regions as promising candidates for further study, which will increase our understanding of the genetic mechanisms underlying growth-related traits in chickens. BioMed Central 2013-03-06 /pmc/articles/PMC3679733/ /pubmed/23497136 http://dx.doi.org/10.1186/1471-2164-14-151 Text en Copyright © 2013 Sheng et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sheng, Zheya
Pettersson, Mats E
Hu, Xiaoxiang
Luo, Chenglong
Qu, Hao
Shu, Dingming
Shen, Xia
Carlborg, Örjan
Li, Ning
Genetic dissection of growth traits in a Chinese indigenous × commercial broiler chicken cross
title Genetic dissection of growth traits in a Chinese indigenous × commercial broiler chicken cross
title_full Genetic dissection of growth traits in a Chinese indigenous × commercial broiler chicken cross
title_fullStr Genetic dissection of growth traits in a Chinese indigenous × commercial broiler chicken cross
title_full_unstemmed Genetic dissection of growth traits in a Chinese indigenous × commercial broiler chicken cross
title_short Genetic dissection of growth traits in a Chinese indigenous × commercial broiler chicken cross
title_sort genetic dissection of growth traits in a chinese indigenous × commercial broiler chicken cross
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679733/
https://www.ncbi.nlm.nih.gov/pubmed/23497136
http://dx.doi.org/10.1186/1471-2164-14-151
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