Biphasic Modulation of NOS Expression, Protein and Nitrite Products by Hydroxocobalamin Underlies Its Protective Effect in Endotoxemic Shock: Downstream Regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 Expression

Background. NOS/(•)NO inhibitors are potential therapeutics for sepsis, yet they increase clinical mortality. However, there has been no in vivo investigation of the (in vitro) (•)NO scavenger, cobalamin's (Cbl) endogenous effects on NOS/(•)NO/inflammatory mediators during the immune response t...

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Detalles Bibliográficos
Autores principales: Sampaio, André L. F., Dalli, Jesmond, Brancaleone, Vincenzo, D'Acquisto, Fulvio, Perretti, Mauro, Wheatley, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679756/
https://www.ncbi.nlm.nih.gov/pubmed/23781123
http://dx.doi.org/10.1155/2013/741804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679756/
https://www.ncbi.nlm.nih.gov/pubmed/23781123
http://dx.doi.org/10.1155/2013/741804

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