NOTCH1 mutations influence survival in chronic lymphocytic leukemia patients

BACKGROUND: NOTCH1 PEST domain mutations in chronic lymphocytic leukemia have recently been shown to be of prognostic relevance. Both NOTCH1 and NOTCH2 are constitutively activated in B-cell CLL but not expressed in normal B cells and may be involved in survival and resistance to apoptosis in CLL. W...

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Detalles Bibliográficos
Autores principales: Willander, Kerstin, Dutta, Ravi Kumar, Ungerbäck, Jonas, Gunnarsson, Rebeqa, Juliusson, Gunnar, Fredrikson, Mats, Linderholm, Mats, Söderkvist, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679784/
https://www.ncbi.nlm.nih.gov/pubmed/23734977
http://dx.doi.org/10.1186/1471-2407-13-274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679784/
https://www.ncbi.nlm.nih.gov/pubmed/23734977
http://dx.doi.org/10.1186/1471-2407-13-274

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