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Identification of thresholds for dichotomizing DNA methylation data

DNA methylation plays an important role in many biological processes by regulating gene expression. It is commonly accepted that turning on the DNA methylation leads to silencing of the expression of the corresponding genes. While methylation is often described as a binary on-off signal, it is typic...

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Detalles Bibliográficos
Autores principales: Liu, Yihua, Ji, Yuan, Qiu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680080/
https://www.ncbi.nlm.nih.gov/pubmed/23742247
http://dx.doi.org/10.1186/1687-4153-2013-8