Pentose Phosphate Pathway Function Affects Tolerance to the G-Quadruplex Binder TMPyP4

G-quadruplexes form in guanine-rich regions of DNA and the presence of these structures at telomeres prevents the activity of telomerase in vitro. Ligands such as the cationic porphyrin TMPyP4 stabilise G-quadruplexes and are therefore under investigation for their potential use as anti-cancer drugs...

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Detalles Bibliográficos
Autores principales: Andrew, Elizabeth J., Merchan, Stephanie, Lawless, Conor, Banks, A. Peter, Wilkinson, Darren J., Lydall, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680382/
https://www.ncbi.nlm.nih.gov/pubmed/23776642
http://dx.doi.org/10.1371/journal.pone.0066242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680382/
https://www.ncbi.nlm.nih.gov/pubmed/23776642
http://dx.doi.org/10.1371/journal.pone.0066242

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