A Novel Strategy to Increase the Proliferative Potential of Adult Human β-Cells While Maintaining Their Differentiated Phenotype

Our previous studies demonstrated that Wnt/GSK-3/β-catenin and mTOR signaling are necessary to stimulate proliferative processes in adult human β-cells. Direct inhibition of GSK-3, that engages Wnt signaling downstream of the Wnt receptor, increases β-catenin nuclear translocation and β-cell prolife...

Descripción completa

Detalles Bibliográficos
Autores principales: Aly, Haytham, Rohatgi, Nidhi, Marshall, Connie A., Grossenheider, Tiffani C., Miyoshi, Hiroyuki, Stappenbeck, Thaddeus S., Matkovich, Scot J., McDaniel, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680388/
https://www.ncbi.nlm.nih.gov/pubmed/23776620
http://dx.doi.org/10.1371/journal.pone.0066131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680388/
https://www.ncbi.nlm.nih.gov/pubmed/23776620
http://dx.doi.org/10.1371/journal.pone.0066131

Ejemplares similares