Stress-Induced Visceral Hypersensitivity in Maternally Separated Rats Can Be Reversed by Peripherally Restricted Histamine-1-Receptor Antagonists

BACKGROUND: The histamine-1 receptor (H1R) antagonist ketotifen increased the threshold of discomfort in hypersensitive IBS patients. The use of peripherally restricted and more selective H1R antagonists may further improve treatment possibilities. We examined the use of fexofenadine and ebastine to...

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Detalles Bibliográficos
Autores principales: Stanisor, Oana I., van Diest, Sophie A., Yu, Zhumei, Welting, Olaf, Bekkali, Noor, Shi, Jing, de Jonge, Wouter J., Boeckxstaens, Guy E., van den Wijngaard, Rene M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680390/
https://www.ncbi.nlm.nih.gov/pubmed/23776699
http://dx.doi.org/10.1371/journal.pone.0066884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680390/
https://www.ncbi.nlm.nih.gov/pubmed/23776699
http://dx.doi.org/10.1371/journal.pone.0066884

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