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Imbalance of SMC1 and SMC3 Cohesins Causes Specific and Distinct Effects

SMC1 and SMC3 form a high-affinity heterodimer, which provides an open backbone of the cohesin ring, to be closed by a kleisin protein. RNAi mediated knock-down of either one heterodimer partner, SMC1 or SMC3, is expected to cause very similar if not identical phenotypes. However, we observed highly...

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Detalles Bibliográficos
Autores principales: Laugsch, Magdalena, Seebach, Jochen, Schnittler, Hans, Jessberger, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680458/
https://www.ncbi.nlm.nih.gov/pubmed/23776448
http://dx.doi.org/10.1371/journal.pone.0065149