Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors

Many inflammatory diseases may be linked to pathologically elevated signaling via the receptor for lipopolysaccharide (LPS), toll-like receptor 4 (TLR4). There has thus been great interest in the discovery of TLR4 inhibitors as potential anti-inflammatory agents. Recently, the structure of TLR4 boun...

Descripción completa

Detalles Bibliográficos
Autores principales: Neal, Matthew D., Jia, Hongpeng, Eyer, Benjamin, Good, Misty, Guerriero, Christopher J., Sodhi, Chhinder P., Afrazi, Amin, Prindle, Thomas, Ma, Congrong, Branca, Maria, Ozolek, John, Brodsky, Jeffrey L., Wipf, Peter, Hackam, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680486/
https://www.ncbi.nlm.nih.gov/pubmed/23776545
http://dx.doi.org/10.1371/journal.pone.0065779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680486/
https://www.ncbi.nlm.nih.gov/pubmed/23776545
http://dx.doi.org/10.1371/journal.pone.0065779

Ejemplares similares