Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2

Checkpoint kinase 2 (CHK2) is an important serine/threonine kinase in the cellular response to DNA damage. A fragment-based screening campaign using a combination of a high-concentration AlphaScreen™ kinase assay and a biophysical thermal shift assay, followed by X-ray crystallography, identified a...

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Detalles Bibliográficos
Autores principales: Silva-Santisteban, M. Cris, Westwood, Isaac M., Boxall, Kathy, Brown, Nathan, Peacock, Sam, McAndrew, Craig, Barrie, Elaine, Richards, Meirion, Mirza, Amin, Oliver, Antony W., Burke, Rosemary, Hoelder, Swen, Jones, Keith, Aherne, G. Wynne, Blagg, Julian, Collins, Ian, Garrett, Michelle D., van Montfort, Rob L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680490/
https://www.ncbi.nlm.nih.gov/pubmed/23776527
http://dx.doi.org/10.1371/journal.pone.0065689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680490/
https://www.ncbi.nlm.nih.gov/pubmed/23776527
http://dx.doi.org/10.1371/journal.pone.0065689

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