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Pharmacophore mapping based inhibitor selection and molecular interaction studies for identification of potential drugs on calcium activated potassium channel blockers, tamulotoxin

BACKGROUND: Tamulotoxin (TmTx) from Buthus tamulus was found to be a highly venomous toxin which accelerates the neurotransmitter release that directly affects the cardiovascular tissues and the respiratory system leading to death. TmTx from red Indian scorpion is a crucial inhibitor for Ca(2+) acti...

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Detalles Bibliográficos
Autores principales: Kumar, R. Barani, Suresh, M. Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680861/
https://www.ncbi.nlm.nih.gov/pubmed/23772102
http://dx.doi.org/10.4103/0973-1296.111239