Fenofibrate administration to arthritic rats increases adiponectin and leptin and prevents oxidative muscle wasting

Chronic inflammation induces skeletal muscle wasting and cachexia. In arthritic rats, fenofibrate, a peroxisome proliferator-activated receptor α (PPARα (PPARA)) agonist, reduces wasting of gastrocnemius, a predominantly glycolytic muscle, by decreasing atrogenes and myostatin. Considering that feno...

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Detalles Bibliográficos
Autores principales: Castillero, Estíbaliz, Martín, Ana Isabel, Nieto-Bona, Maria Paz, Fernández-Galaz, Carmen, López-Menduiña, María, Villanúa, María Ángeles, López-Calderón, Asunción
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioScientifica 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681315/
https://www.ncbi.nlm.nih.gov/pubmed/23781298
http://dx.doi.org/10.1530/EC-12-0003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681315/
https://www.ncbi.nlm.nih.gov/pubmed/23781298
http://dx.doi.org/10.1530/EC-12-0003

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