Impact of Ribosomal Modification on the Binding of the Antibiotic Telithromycin Using a Combined Grand Canonical Monte Carlo/Molecular Dynamics Simulation Approach

Resistance to macrolide antibiotics is conferred by mutation of A2058 to G or methylation by Erm methyltransferases of the exocyclic N6 of A2058 (E. coli numbering) that forms the macrolide binding site in the 50S subunit of the ribosome. Ketolides such as telithromycin mitigate A2058G resistance ye...

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Detalles Bibliográficos
Autores principales: Small, Meagan C., Lopes, Pedro, Andrade, Rodrigo B., MacKerell, Alexander D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681621/
https://www.ncbi.nlm.nih.gov/pubmed/23785274
http://dx.doi.org/10.1371/journal.pcbi.1003113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681621/
https://www.ncbi.nlm.nih.gov/pubmed/23785274
http://dx.doi.org/10.1371/journal.pcbi.1003113

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