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Fragile DNA Motifs Trigger Mutagenesis at Distant Chromosomal Loci in Saccharomyces cerevisiae

DNA sequences capable of adopting non-canonical secondary structures have been associated with gross-chromosomal rearrangements in humans and model organisms. Previously, we have shown that long inverted repeats that form hairpin and cruciform structures and triplex-forming GAA/TTC repeats induce th...

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Detalles Bibliográficos
Autores principales: Saini, Natalie, Zhang, Yu, Nishida, Yuri, Sheng, Ziwei, Choudhury, Shilpa, Mieczkowski, Piotr, Lobachev, Kirill S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681665/
https://www.ncbi.nlm.nih.gov/pubmed/23785298
http://dx.doi.org/10.1371/journal.pgen.1003551