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Unsupervised Clustering of Subcellular Protein Expression Patterns in High-Throughput Microscopy Images Reveals Protein Complexes and Functional Relationships between Proteins

Protein subcellular localization has been systematically characterized in budding yeast using fluorescently tagged proteins. Based on the fluorescence microscopy images, subcellular localization of many proteins can be classified automatically using supervised machine learning approaches that have b...

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Detalles Bibliográficos
Autores principales: Handfield, Louis-François, Chong, Yolanda T., Simmons, Jibril, Andrews, Brenda J., Moses, Alan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681667/
https://www.ncbi.nlm.nih.gov/pubmed/23785265
http://dx.doi.org/10.1371/journal.pcbi.1003085