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The mitochondrial Hsp70 chaperone Ssq1 facilitates Fe/S cluster transfer from Isu1 to Grx5 by complex formation

The mitochondrial Hsp70 chaperone Ssq1 plays a dedicated role in the maturation of iron–sulfur (Fe/S) proteins, an essential process of mitochondria. Similar to its bacterial orthologue HscA, Ssq1 binds to the scaffold protein Isu1, thereby facilitating dissociation of the newly synthesized Fe/S clu...

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Detalles Bibliográficos
Autores principales: Uzarska, Marta A., Dutkiewicz, Rafal, Freibert, Sven-Andreas, Lill, Roland, Mühlenhoff, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681689/
https://www.ncbi.nlm.nih.gov/pubmed/23615440
http://dx.doi.org/10.1091/mbc.E12-09-0644