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JNK1/2 regulates ER–mitochondrial Ca(2+) cross-talk during IL-1β–mediated cell death in RINm5F and human primary β-cells
Elevated interleukin-1β (IL-1β) induces apoptosis in pancreatic β-cells through endoplasmic reticulum (ER) stress induction and subsequent c-jun-N-terminal kinase 1/2 (JNK1/2) activation. In earlier work we showed that JNK1/2 activation is initiated before ER stress and apoptotic induction in respon...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681707/ https://www.ncbi.nlm.nih.gov/pubmed/23615449 http://dx.doi.org/10.1091/mbc.E12-12-0885 |