Characterizing the Membrane-Bound State of Cytochrome P450 3A4: Structure, Depth of Insertion, and Orientation

[Image: see text] Cytochrome P450 3A4 (CYP3A4) is the most abundant membrane-associated isoform of the P450 family in humans and is responsible for biotransformation of more than 50% of drugs metabolized in the body. Despite the large number of crystallographic structures available for CYP3A4, no st...

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Detalles Bibliográficos
Autores principales: Baylon, Javier L., Lenov, Ivan L., Sligar, Stephen G., Tajkhorshid, Emad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682445/
https://www.ncbi.nlm.nih.gov/pubmed/23697766
http://dx.doi.org/10.1021/ja4003525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682445/
https://www.ncbi.nlm.nih.gov/pubmed/23697766
http://dx.doi.org/10.1021/ja4003525

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