Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor

FFA2 is a G protein-coupled receptor that responds to short chain fatty acids and has generated interest as a therapeutic target for metabolic and inflammatory conditions. However, definition of its functions has been slowed by a dearth of selective ligands that can distinguish it from the closely r...

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Detalles Bibliográficos
Autores principales: Hudson, Brian D., Due-Hansen, Maria E., Christiansen, Elisabeth, Hansen, Anna Mette, Mackenzie, Amanda E., Murdoch, Hannah, Pandey, Sunil K., Ward, Richard J., Marquez, Rudi, Tikhonova, Irina G., Ulven, Trond, Milligan, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682533/
https://www.ncbi.nlm.nih.gov/pubmed/23589301
http://dx.doi.org/10.1074/jbc.M113.455337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682533/
https://www.ncbi.nlm.nih.gov/pubmed/23589301
http://dx.doi.org/10.1074/jbc.M113.455337

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