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Effects of gene regulatory reprogramming on gene expression in human and mouse developing hearts
Lineage-specific regulatory elements underlie adaptation of species and play a role in disease susceptibility. We compared functionally conserved and lineage-specific enhancers by cross-mapping 5042 human and 6564 mouse heart enhancers. Of these, 79 per cent are lineage-specific, lacking a functiona...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682729/ https://www.ncbi.nlm.nih.gov/pubmed/23650638 http://dx.doi.org/10.1098/rstb.2012.0366 |