Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells

BACKGROUND: In mouse embryonic stem cells (mESCs), transcriptional silencing of numerous class I and II endogenous retroviruses (ERVs), including IAP, ETn and MMERVK10C, is dependent upon the H3K9 methyltransferase (KMTase) SETDB1/ESET and its binding partner KAP1/TRIM28. In contrast, the H3K9 KMTas...

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Detalles Bibliográficos
Autores principales: Maksakova, Irina A, Thompson, Peter J, Goyal, Preeti, Jones, Steven JM, Singh, Prim B, Karimi, Mohammad M, Lorincz, Matthew C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682905/
https://www.ncbi.nlm.nih.gov/pubmed/23735015
http://dx.doi.org/10.1186/1756-8935-6-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682905/
https://www.ncbi.nlm.nih.gov/pubmed/23735015
http://dx.doi.org/10.1186/1756-8935-6-15

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