Enterocyte-Specific Inactivation of SIRT1 Reduces Tumor Load in the APC(+/min) Mouse Model

SIRT1 is a mammalian NAD(+)-dependent histone deacetylase implicated in metabolism, development, aging and tumorigenesis. Prior studies that examined the effect of enterocyte-specific overexpression and global deletion of SIRT1 on polyp formation in the intestines of APC(+/min) mice, a commonly used...

Descripción completa

Detalles Bibliográficos
Autores principales: Leko, Vid, Park, Gemma J., Lao, Uyen, Simon, Julian A., Bedalov, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682947/
https://www.ncbi.nlm.nih.gov/pubmed/23799088
http://dx.doi.org/10.1371/journal.pone.0066283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682947/
https://www.ncbi.nlm.nih.gov/pubmed/23799088
http://dx.doi.org/10.1371/journal.pone.0066283

Ejemplares similares