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Enterocyte-Specific Inactivation of SIRT1 Reduces Tumor Load in the APC(+/min) Mouse Model

SIRT1 is a mammalian NAD(+)-dependent histone deacetylase implicated in metabolism, development, aging and tumorigenesis. Prior studies that examined the effect of enterocyte-specific overexpression and global deletion of SIRT1 on polyp formation in the intestines of APC(+/min) mice, a commonly used...

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Detalles Bibliográficos
Autores principales:	Leko, Vid, Park, Gemma J., Lao, Uyen, Simon, Julian A., Bedalov, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682947/ https://www.ncbi.nlm.nih.gov/pubmed/23799088 http://dx.doi.org/10.1371/journal.pone.0066283

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