Cancer Missense Mutations Alter Binding Properties of Proteins and Their Interaction Networks

Many studies have shown that missense mutations might play an important role in carcinogenesis. However, the extent to which cancer mutations might affect biomolecular interactions remains unclear. Here, we map glioblastoma missense mutations on the human protein interactome, model the structures of...

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Detalles Bibliográficos
Autores principales: Nishi, Hafumi, Tyagi, Manoj, Teng, Shaolei, Shoemaker, Benjamin A., Hashimoto, Kosuke, Alexov, Emil, Wuchty, Stefan, Panchenko, Anna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682950/
https://www.ncbi.nlm.nih.gov/pubmed/23799087
http://dx.doi.org/10.1371/journal.pone.0066273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682950/
https://www.ncbi.nlm.nih.gov/pubmed/23799087
http://dx.doi.org/10.1371/journal.pone.0066273

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