Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis

Genetic evidence links mutations in the LRRK2 gene with an increased risk of Parkinson’s disease, for which no neuroprotective or neurorestorative therapies currently exist. While the role of LRRK2 in normal cellular function has yet to be fully described, evidence suggests involvement with immune a...

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Detalles Bibliográficos
Autores principales: Ness, Daniel, Ren, Zhao, Gardai, Shyra, Sharpnack, Douglas, Johnson, Victor J., Brennan, Richard J., Brigham, Elizabeth F., Olaharski, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682960/
https://www.ncbi.nlm.nih.gov/pubmed/23799078
http://dx.doi.org/10.1371/journal.pone.0066164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682960/
https://www.ncbi.nlm.nih.gov/pubmed/23799078
http://dx.doi.org/10.1371/journal.pone.0066164

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