Is Dynamic Autocrine Insulin Signaling Possible? A Mathematical Model Predicts Picomolar Concentrations of Extracellular Monomeric Insulin within Human Pancreatic Islets

Insulin signaling is essential for [Image: see text]-cell survival and proliferation in vivo. Insulin also has potent mitogenic and anti-apoptotic actions on cultured [Image: see text]-cells, with maximum effect in the high picomolar range and diminishing effect at high nanomolar doses. In order to...

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Detalles Bibliográficos
Autores principales: Wang, Minghu, Li, Jiaxu, Lim, Gareth E., Johnson, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682990/
https://www.ncbi.nlm.nih.gov/pubmed/23798995
http://dx.doi.org/10.1371/journal.pone.0064860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682990/
https://www.ncbi.nlm.nih.gov/pubmed/23798995
http://dx.doi.org/10.1371/journal.pone.0064860

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