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Is Dynamic Autocrine Insulin Signaling Possible? A Mathematical Model Predicts Picomolar Concentrations of Extracellular Monomeric Insulin within Human Pancreatic Islets
Insulin signaling is essential for [Image: see text]-cell survival and proliferation in vivo. Insulin also has potent mitogenic and anti-apoptotic actions on cultured [Image: see text]-cells, with maximum effect in the high picomolar range and diminishing effect at high nanomolar doses. In order to...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682990/ https://www.ncbi.nlm.nih.gov/pubmed/23798995 http://dx.doi.org/10.1371/journal.pone.0064860 |