Long-Term Stabilization Effects of Leptin on Brain Functions in a Leptin-Deficient Patient

CONTEXT: Congenital leptin deficiency, caused by a very rare mutation in the gene encoding leptin, leads to severe obesity, hyperphagia and impaired satiety. The only systemic treatment is the substitution with metreleptin leading to weight reduction based on hormonal changes. Several studies have a...

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Detalles Bibliográficos
Autores principales: Frank, Sabine, Heni, Martin, Moss, Anja, von Schnurbein, Julia, Farooqi, Sadaf, Häring, Hans-Ulrich, Fritsche, Andreas, Preissl, Hubert, Wabitsch, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683048/
https://www.ncbi.nlm.nih.gov/pubmed/23799059
http://dx.doi.org/10.1371/journal.pone.0065893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683048/
https://www.ncbi.nlm.nih.gov/pubmed/23799059
http://dx.doi.org/10.1371/journal.pone.0065893

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