RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

The protein-tyrosine phosphatase SHP-1 plays critical roles in immune signaling, but how mutations in SHP-1 cause inflammatory disease in humans remains poorly defined(1). Mice homozygous for the Y208N amino acid substitution in the carboxy-terminus of SHP-1 (referred to as Ptpn6(spin) mice) spontan...

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Detalles Bibliográficos
Autores principales: Lukens, John R., Vogel, Peter, Johnson, Gordon R., Kelliher, Michelle A., Iwakura, Yoichiro, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683390/
https://www.ncbi.nlm.nih.gov/pubmed/23708968
http://dx.doi.org/10.1038/nature12174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683390/
https://www.ncbi.nlm.nih.gov/pubmed/23708968
http://dx.doi.org/10.1038/nature12174

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