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RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3
The protein-tyrosine phosphatase SHP-1 plays critical roles in immune signaling, but how mutations in SHP-1 cause inflammatory disease in humans remains poorly defined(1). Mice homozygous for the Y208N amino acid substitution in the carboxy-terminus of SHP-1 (referred to as Ptpn6(spin) mice) spontan...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683390/ https://www.ncbi.nlm.nih.gov/pubmed/23708968 http://dx.doi.org/10.1038/nature12174 |