BID-induced structural changes in BAK promote apoptosis

The BCL-2 family protein BAK is responsible for mitochondrial outer membrane permeabilization (MOMP), which leads to apoptosis. The BCL-2 homology (BH) 3-only protein BID activates BAK to perform this function. We report the NMR solution structure of the human BID BH3–BAK complex, which identified t...

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Detalles Bibliográficos
Autores principales: Moldoveanu, Tudor, Grace, Christy R., Llambi, Fabien, Nourse, Amanda, Fitzgerald, Patrick, Gehring, Kalle, Kriwacki, Richard W., Green, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683554/
https://www.ncbi.nlm.nih.gov/pubmed/23604079
http://dx.doi.org/10.1038/nsmb.2563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683554/
https://www.ncbi.nlm.nih.gov/pubmed/23604079
http://dx.doi.org/10.1038/nsmb.2563

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