Cargando…

Roles Nrf2 Plays in Myeloid Cells and Related Disorders

The Keap1-Nrf2 system protects animals from oxidative and electrophilic stresses. Nrf2 is a transcription factor that induces the expression of genes essential for detoxifying reactive oxygen species (ROS) and cytotoxic electrophiles. Keap1 is a stress sensor protein that binds to and ubiquitinates...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kobayashi, Eri, Suzuki, Takafumi, Yamamoto, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684031/ https://www.ncbi.nlm.nih.gov/pubmed/23819012 http://dx.doi.org/10.1155/2013/529219

Ejemplares similares

Nrf2 plays a critical role in the metabolic response during and after spaceflight
por: Uruno, Akira, et al.
Publicado: (2021)

Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
por: Suzuki, Takafumi, et al.
Publicado: (2017)

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
por: Kobayashi, Eri H., et al.
Publicado: (2016)

Molecular Basis of the KEAP1-NRF2 Signaling Pathway
por: Suzuki, Takafumi, et al.
Publicado: (2023)

Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2018)

Multifaceted Roles of the KEAP1–NRF2 System in Cancer and Inflammatory Disease Milieu
por: Panda, Harit, et al.
Publicado: (2022)

A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells
por: Baird, Liam, et al.
Publicado: (2023)

The Role of NRF2 in Mycobacterial Infection
por: Matsuyama, Masashi, et al.
Publicado: (2021)

Cerebrovascular and Neurological Disorders: Protective Role of NRF2
por: Sivandzade, Farzane, et al.
Publicado: (2019)

AHR and NRF2 in Skin Homeostasis and Atopic Dermatitis
por: Edamitsu, Tomohiro, et al.
Publicado: (2022)

The KEAP1-NRF2 System and Esophageal Cancer
por: Hirose, Wataru, et al.
Publicado: (2022)

New addiction to the NRF2‐related factor NRF3 in cancer cells: Ubiquitin‐independent proteolysis through the 20S proteasome
por: Kobayashi, Akira, et al.
Publicado: (2019)

The KEAP1–NRF2 System as a Molecular Target of Cancer Treatment
por: Taguchi, Keiko, et al.
Publicado: (2020)

Does Pyroptosis Play a Role in Inflammasome-Related Disorders?
por: Zhang, Jiajia, et al.
Publicado: (2022)

Nrf2-Related Therapeutic Effects of Curcumin in Different Disorders
por: Ghafouri-Fard, Soudeh, et al.
Publicado: (2022)

Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice
por: Shimizu, Ritsuko, et al.
Publicado: (2023)

Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2
por: Karathedath, Sreeja, et al.
Publicado: (2017)

Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production
por: Cvetko, Filip, et al.
Publicado: (2020)

Immunoediting of KEAP1-NRF2 mutant tumours is required to circumvent NRF2-mediated immune surveillance
por: Baird, Liam, et al.
Publicado: (2023)

Roles of Nrf2 in Protecting the Kidney from Oxidative Damage
por: Nezu, Masahiro, et al.
Publicado: (2020)

Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight
por: Hayashi, Takuto, et al.
Publicado: (2021)

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
por: Dodson, Matthew, et al.
Publicado: (2019)

The KEAP1–NRF2 System in Cancer
por: Taguchi, Keiko, et al.
Publicado: (2017)

Abnormal expression of Nrf2 may play an important role in the pathogenesis and development of adenomyosis
por: Chen, Ning, et al.
Publicado: (2017)

Insights into the Regulation of GFR by the Keap1-Nrf2 Pathway
por: Kidokoro, Kengo, et al.
Publicado: (2023)

Nrf2 is highly expressed in neutrophils, but myeloid cell-derived Nrf2 is dispensable for wound healing in mice
por: Joshi, Natasha, et al.
Publicado: (2017)

Intrinsically disordered proteins play diverse roles in cell signaling
por: Bondos, Sarah E., et al.
Publicado: (2022)

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism
por: Horie, Yuta, et al.
Publicado: (2021)

Roles of CNC Transcription Factors NRF1 and NRF2 in Cancer
por: Sekine, Hiroki, et al.
Publicado: (2021)

The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2021)

Exosomes and Extracellular Vesicles in Myeloid Neoplasia: The Multiple and Complex Roles Played by These “Magic Bullets”
por: Bernardi, Simona, et al.
Publicado: (2021)

A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection in Vitro, and Hepatoprotection in Vivo by Bardoxolone Methyl (CDDO-Me)
por: Gatbonton-Schwager, Tonibelle, et al.
Publicado: (2023)

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2018)

Role of Nrf2 in bone metabolism
por: Sun, Yong-Xin, et al.
Publicado: (2015)

Role of NRF2 in Lung Cancer
por: Sánchez-Ortega, Miriam, et al.
Publicado: (2021)

Role of Nrf2 in Pancreatic Cancer
por: Cykowiak, Marta, et al.
Publicado: (2021)

Role of NRF2 in Ovarian Cancer
por: Tossetta, Giovanni, et al.
Publicado: (2022)

Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury
por: Ashino, Takashi, et al.
Publicado: (2016)

Roles of NRF3 in the Hallmarks of Cancer: Proteasomal Inactivation of Tumor Suppressors
por: Kobayashi, Akira
Publicado: (2020)

The role of transcription factor Nrf2 in skin cells metabolism
por: Gęgotek, Agnieszka, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kcdbi4set23vf38k8ofvb1kc1e