Chemical Genetics Identify eIF2α Kinase Heme Regulated Inhibitor as Anti-Cancer Target

Translation initiation plays a critical role in cellular homeostasis, proliferation, differentiation and malignant transformation. Consistently, increasing the abundance of the eIF2·GTP·Met-tRNA(i) translation initiation complex transforms normal cells and contributes to cancer initiation and the se...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Ting, Ozel, Duygu, Qiao, Yuan, Harbinski, Fred, Chen, Limo, Denoyelle, Séverine, He, Xiaoying, Zvereva, Nela, Supko, Jeffrey G., Chorev, Michael, Halperin, Jose A., Aktas, Bertal H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684262/
https://www.ncbi.nlm.nih.gov/pubmed/21765405
http://dx.doi.org/10.1038/nchembio.613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684262/
https://www.ncbi.nlm.nih.gov/pubmed/21765405
http://dx.doi.org/10.1038/nchembio.613

Ejemplares similares