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Chemical Genetics Identify eIF2α Kinase Heme Regulated Inhibitor as Anti-Cancer Target

Translation initiation plays a critical role in cellular homeostasis, proliferation, differentiation and malignant transformation. Consistently, increasing the abundance of the eIF2·GTP·Met-tRNA(i) translation initiation complex transforms normal cells and contributes to cancer initiation and the se...

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Detalles Bibliográficos
Autores principales:	Chen, Ting, Ozel, Duygu, Qiao, Yuan, Harbinski, Fred, Chen, Limo, Denoyelle, Séverine, He, Xiaoying, Zvereva, Nela, Supko, Jeffrey G., Chorev, Michael, Halperin, Jose A., Aktas, Bertal H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684262/ https://www.ncbi.nlm.nih.gov/pubmed/21765405 http://dx.doi.org/10.1038/nchembio.613

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