Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000

BACKGROUND: ML 3000 ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid) is an inhibitor of both cyclooxygenase and 5-lipoxygenase in vitro, and shows promise as a novel non-steroidal anti-inflammatory drug (NSAID). Unlike conventional NSAIDs which are associated...

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Detalles Bibliográficos
Autores principales: Smolka, Adam J, Goldenring, James R, Gupta, Sandeep, Hammond, Charles E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC368434/
https://www.ncbi.nlm.nih.gov/pubmed/15028114
http://dx.doi.org/10.1186/1471-230X-4-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC368434/
https://www.ncbi.nlm.nih.gov/pubmed/15028114
http://dx.doi.org/10.1186/1471-230X-4-4

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