Similar dose-dependence of motor neuron cell death caused by wild type human TDP-43 and mutants with ALS-associated amino acid substitutions

BACKGROUND: TDP-43, a multi-functional DNA/ RNA-binding protein encoded by the TARDBP gene, has emerged as a major patho-signature factor of the ubiquitinated intracellular inclusions (UBIs) in the diseased cells of a range of neurodegenerative diseases. Mutations in at least 9 different genes inclu...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Lien-Szu, Cheng, Wei-Cheng, Shen, Che-Kun James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684520/
https://www.ncbi.nlm.nih.gov/pubmed/23721326
http://dx.doi.org/10.1186/1423-0127-20-33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684520/
https://www.ncbi.nlm.nih.gov/pubmed/23721326
http://dx.doi.org/10.1186/1423-0127-20-33

Ejemplares similares