Cargando…

Celastrol Prevents Atherosclerosis via Inhibiting LOX-1 and Oxidative Stress

Celastrol is a triterpenoid compound extracted from the Chinese herb Tripterygium wilfordii Hook F. Previous research has revealed its anti-oxidant, anti-inflammatory, anti-cancer and immunosuppressive properties. Here, we investigated whether celastrol inhibits oxidized low-density lipoprotein (oxL...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Lei, Bai, Wenli, Li, Sha, Zhang, Yuqing, Han, Yi, Gu, Yue, Meng, Guoliang, Xie, Liping, Wang, Jing, Xiao, Yujiao, Shan, Liyang, Zhou, Suming, Wei, Lei, Ferro, Albert, Ji, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684610/ https://www.ncbi.nlm.nih.gov/pubmed/23799016 http://dx.doi.org/10.1371/journal.pone.0065477

Ejemplares similares

GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats
por: Meng, Guoliang, et al.
Publicado: (2015)

Direct Renin Inhibition With Aliskiren Protects Against Myocardial Ischemia/Reperfusion Injury by Activating Nitric Oxide Synthase Signaling in Spontaneously Hypertensive Rats
por: Zhang, Wen, et al.
Publicado: (2014)

LOX-1, OxLDL, and Atherosclerosis
por: Pirillo, Angela, et al.
Publicado: (2013)

LOX-1: Implications in atherosclerosis and myocardial ischemia
por: Sharma, Tanya, et al.
Publicado: (2022)

LOX-1: Regulation, Signaling and Its Role in Atherosclerosis
por: Kattoor, Ajoe John, et al.
Publicado: (2019)

Celastrol Attenuates Lipid Accumulation and Stemness of Clear Cell Renal Cell Carcinoma via CAV-1/LOX-1 Pathway
por: Zhang, Chan-Juan, et al.
Publicado: (2021)

Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset
por: Di Rienzo, Carmine, et al.
Publicado: (2013)

Autophagy in the pharmacological activities of celastrol (Review)
por: Zhang, Caixia, et al.
Publicado: (2023)

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids
por: Wang, Huabo, et al.
Publicado: (2015)

Systematic identification of Celastrol-binding proteins reveals that Shoc2 is inhibited by Celastrol
por: Xiao-pei, Huang, et al.
Publicado: (2018)

Oxidized LDL and LOX-1 in Experimental Sepsis
por: Al-Banna, Nadia, et al.
Publicado: (2013)

Fisetin ameliorates atherosclerosis by regulating PCSK9 and LOX-1 in apoE(-/-) mice
por: Yan, Li, et al.
Publicado: (2021)

Celastrol-based nanomedicine promotes corneal allograft survival
por: Li, Zhanrong, et al.
Publicado: (2021)

Correction: Systematic identification of celastrol-binding proteins reveals that Shoc2 is inhibited by celastrol
Publicado: (2021)

Induction of the ER stress response in NRVMs is linked to cardiotoxicity caused by celastrol: Celastrol cardiotoxicity involves the ER stress response
por: Chen, Zhong, et al.
Publicado: (2022)

Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors
por: Sheng, Ping, et al.
Publicado: (2023)

Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling
por: Jiang, Zhitao, et al.
Publicado: (2019)

l-Tetrahydropalmatine, an Active Component of Corydalis yanhusuo W.T. Wang, Protects against Myocardial Ischaemia-Reperfusion Injury in Rats
por: Han, Yi, et al.
Publicado: (2012)

Identification of the LOX Gene Family in Peanut and Functional Characterization of AhLOX29 in Drought Tolerance
por: Mou, Yifei, et al.
Publicado: (2022)

The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery
por: Xiao, Simeng, et al.
Publicado: (2023)

LOX-1 and Its Splice Variants: A New Challenge for Atherosclerosis and Cancer-Targeted Therapies
por: Rizzacasa, Barbara, et al.
Publicado: (2017)

17ß-Estradiol Antagonizes the Down-Regulation of ERα/NOS-3 Signaling in Vascular Endothelial Dysfunction of Female Diabetic Rats
por: Han, Yi, et al.
Publicado: (2012)

Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis
por: Meng, Guoliang, et al.
Publicado: (2015)

Synthesis and characterisation of celastrol derivatives as potential anticancer agents
por: Zhang, Hong-Jian, et al.
Publicado: (2017)

Improved scFv Anti-LOX-1 Binding Activity by Fusion with LOX-1-Binding Peptides
por: Hu, Wei, et al.
Publicado: (2017)

Targeting OPA1-Mediated Mitochondrial Fusion Contributed to Celastrol’s Anti-Tumor Angiogenesis Effect
por: Li, Gaofu, et al.
Publicado: (2022)

Effectively suppressed angiogenesis-mediated retinoblastoma growth using celastrol nanomicelles
por: Li, Zhanrong, et al.
Publicado: (2020)

MicroRNA let-7g alleviates atherosclerosis via the targeting of LOX-1 in vitro and in vivo
por: Liu, Mingxin, et al.
Publicado: (2017)

Aerobic Exercise Training Inhibits Neointimal Formation via Reduction of PCSK9 and LOX-1 in Atherosclerosis
por: Li, Wei, et al.
Publicado: (2020)

The LOX-1 receptor ectopically expressed in the liver alleviates atherosclerosis by clearing Ox-LDL from the circulation
por: Wang, Zhiwen, et al.
Publicado: (2022)

Reducing the Damage of Ox-LDL/LOX-1 Pathway to Vascular Endothelial Barrier Can Inhibit Atherosclerosis
por: Guo, Xiaopeng, et al.
Publicado: (2022)

The Potential Therapeutic Role of Celastrol in Patients With Heart Failure With Preserved Ejection Fraction
por: Ajmal, Maryam, et al.
Publicado: (2021)

Formulation and Evaluation of Celastrol-Loaded Liposomes
por: Song, Jie, et al.
Publicado: (2011)

Replacing the wild type loxP site in BACs from the public domain with lox66 using a lox66 transposon
por: Chatterjee, Pradeep K, et al.
Publicado: (2010)

Potential mechanisms of action of celastrol against rheumatoid arthritis: Transcriptomic and proteomic analysis
por: Xinqiang, Song, et al.
Publicado: (2020)

Serum Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 (sLOX-1) Is Associated with Atherosclerosis Severity in Coronary Artery Disease
por: Kott, Katharine A., et al.
Publicado: (2023)

Celastrol promotes chondrocyte autophagy by regulating mTOR expression
por: Dai, Siming, et al.
Publicado: (2022)

Protective Effects of Chinese Traditional Medicine Longhu Rendan against Atherosclerosis via Negative Regulation of LOX-1
por: Yan, Sishan, et al.
Publicado: (2018)

Celastrol: An Update on Its Hepatoprotective Properties and the Linked Molecular Mechanisms
por: Li, Mengzhen, et al.
Publicado: (2022)

Celastrol alleviates comorbid obesity and depression by directly binding amygdala HnRNPA1 in a mouse model
por: Zhu, Chunyan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1ru62bd5lfrjnu7mu982qr3nvq