Tau phosphorylation affects its axonal transport and degradation

Phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary tangles in Alzheimer's disease. To investigate the effects of specific phosphorylated tau residues on its function, wild type or phosphomutant tau was expressed in cells. Elevated tau phosphorylation decrea...

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Detalles Bibliográficos
Autores principales: Rodríguez-Martín, Teresa, Cuchillo-Ibáñez, Inmaculada, Noble, Wendy, Nyenya, Fanon, Anderton, Brian H., Hanger, Diane P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684773/
https://www.ncbi.nlm.nih.gov/pubmed/23601672
http://dx.doi.org/10.1016/j.neurobiolaging.2013.03.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684773/
https://www.ncbi.nlm.nih.gov/pubmed/23601672
http://dx.doi.org/10.1016/j.neurobiolaging.2013.03.015

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