Cargando…

Tau phosphorylation affects its axonal transport and degradation

Phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary tangles in Alzheimer's disease. To investigate the effects of specific phosphorylated tau residues on its function, wild type or phosphomutant tau was expressed in cells. Elevated tau phosphorylation decrea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodríguez-Martín, Teresa, Cuchillo-Ibáñez, Inmaculada, Noble, Wendy, Nyenya, Fanon, Anderton, Brian H., Hanger, Diane P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2013
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684773/ https://www.ncbi.nlm.nih.gov/pubmed/23601672 http://dx.doi.org/10.1016/j.neurobiolaging.2013.03.015

Ejemplares similares

Functional Implications of Glycogen Synthase Kinase-3-Mediated Tau Phosphorylation
por: Hanger, Diane P., et al.
Publicado: (2011)

The Importance of Tau Phosphorylation for Neurodegenerative Diseases
por: Noble, Wendy, et al.
Publicado: (2013)

The microtubule-associated protein tau is phosphorylated by Syk
por: Lebouvier, Thibaud, et al.
Publicado: (2008)

Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease
por: Lau, Dawn H. W., et al.
Publicado: (2016)

Roles of tau protein in health and disease
por: Guo, Tong, et al.
Publicado: (2017)

A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response
por: Guo, Tong, et al.
Publicado: (2019)

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies
por: Giacomini, Caterina, et al.
Publicado: (2018)

Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments
por: Ackerley, Steven, et al.
Publicado: (2003)

Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport
por: Le, Michelle H., et al.
Publicado: (2016)

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons
por: Rodríguez-Martín, Teresa, et al.
Publicado: (2016)

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture
por: Garwood, C J, et al.
Publicado: (2011)

Physiological release of endogenous tau is stimulated by neuronal activity
por: Pooler, Amy M, et al.
Publicado: (2013)

Inhibition of glycogen synthase kinase-3 by BTA-EG(4) reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer’s disease
por: Croft, Cara L., et al.
Publicado: (2017)

Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β
por: Povellato, Giulia, et al.
Publicado: (2013)

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain
por: Kurbatskaya, Ksenia, et al.
Publicado: (2016)

Tau phosphorylation and PAD exposure in regulation of axonal growth
por: Morris, S. L., et al.
Publicado: (2023)

Slow Axonal Transport of Neurofilament Protein in Cultured Neurons
por: Koehnle, Thomas J., et al.
Publicado: (1999)

Neurofilament-dependent Radial Growth of Motor Axons and Axonal Organization of Neurofilaments Does Not Require the Neurofilament Heavy Subunit (NF-H) or Its Phosphorylation
por: Rao, Mala V., et al.
Publicado: (1998)

Drosophila modelling axonal transport in the face of tau pathology
por: Mudher, Amrit
Publicado: (2015)

Ca(2+)-induced Ca(2+) Release in Chromaffin Cells Seen from inside the ER with Targeted Aequorin
por: Alonso, Maria Teresa, et al.
Publicado: (1999)

Glutamate Slows Axonal Transport of Neurofilaments in Transfected Neurons
por: Ackerley, Steven, et al.
Publicado: (2000)

Phosphorylated Tau protein in the myenteric plexus of the ileum and colon of normothermic rats and during synthetic torpor
por: Chiocchetti, R, et al.
Publicado: (2021)

Bridging integrator 1 protein loss in Alzheimer’s disease promotes synaptic tau accumulation and disrupts tau release
por: Glennon, Elizabeth B, et al.
Publicado: (2020)

An open-type microdevice to improve the quality of fluorescence labeling for axonal transport analysis in neurons
por: Yokoyama, S., et al.
Publicado: (2019)

Editorial: Tau Propagation Mechanisms: Cell Models, Animal Models, and Beyond
por: Motoi, Yumiko, et al.
Publicado: (2020)

Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn
por: Scales, Timothy ME, et al.
Publicado: (2011)

Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1
por: Iijima-Ando, Kanae, et al.
Publicado: (2012)

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate
por: Bondulich, Marie K., et al.
Publicado: (2016)

Vesicular Axonal Transport is Modified In Vivo by Tau Deletion or Overexpression in Drosophila
por: Talmat-Amar, Yasmina, et al.
Publicado: (2018)

Emergence of directional bias in tau deposition from axonal transport dynamics
por: Torok, Justin, et al.
Publicado: (2021)

Usp14 Deficiency Increases Tau Phosphorylation without Altering Tau Degradation or Causing Tau-Dependent Deficits
por: Jin, Youngnam N., et al.
Publicado: (2012)

Axonal transport declines with age in two distinct phases separated by a period of relative stability()
por: Milde, Stefan, et al.
Publicado: (2015)

Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein
por: Mórotz, Gábor M., et al.
Publicado: (2019)

Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures
por: Croft, Cara L, et al.
Publicado: (2017)

Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport
por: Rao, Mala V., et al.
Publicado: (2002)

DNA Damage, Neurodegeneration, and Synaptic Plasticity
por: Merlo, Daniela, et al.
Publicado: (2016)

Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer’s disease
por: Boix, Claudia P., et al.
Publicado: (2020)

Anti-Inflammatory Impact of Minocycline in a Mouse Model of Tauopathy
por: Garwood, Claire J., et al.
Publicado: (2010)

Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation
por: Hayden, Eric Y., et al.
Publicado: (2019)

Role of Us9 Phosphorylation in Axonal Sorting and Anterograde Transport of Pseudorabies Virus
por: Kratchmarov, Radomir, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_8ivglirohvcqfcckhgv7pv7loa